A REVIEW ON IMMEDIATE RELEASE DRUG DELIVERY SYSTEM BY USING DESIGN OF EXPERIMENT

Abstract

Tablet is the most popular among all dosage forms existing today because of its convenience of self administration, compactness and easy manufacturing;  Sometimes immediate onset of action is required than conventional therapy in many cases. Tablets are the most popular dosage form because of its unique properties such as ease of administration, low cost and non-invasive therapy etc .Therapeutic success of any therapy depends on the patient’s compliance toward the therapy. As a drug entity nears the end of its patent life, it is common for pharmaceutical manufacturers to develop a given drug entity in a new and improved dosage form. To provide the patients with the most convenient mode of administration, there was a need to develop immediate release dosage form, particularly one that disintegrates rapidly and disperses and helps in enhancing stearate. Immediate drug release dosage forms disintegrate rapidly after administration with enhanced rate of dissolution.  Direct compressed method was adapted to prepare the tablets by using different excipient microcrystalline cellulose, lactose, pregelatinized starch, croscarmellose sodium, talc, sodium starch glycolate, magnesium. A new dosage form allows a manufacturer to extend market exclusivity, while offering its patient population a more convenient dosage form or dosing regimen. 

Key Words: Immediate release, direct compression, super-disintegrants